Subject(s)
Allergy and Immunology/trends , Animals, Domestic/immunology , Animals, Wild/immunology , Communicable Diseases, Emerging/immunology , Communicable Diseases, Emerging/prevention & control , Ecosystem , Animals , COVID-19 , Chiroptera , Communicable Diseases, Emerging/veterinary , Coronavirus Infections/immunology , Coronavirus Infections/prevention & control , Coronavirus Infections/veterinary , Disease Models, Animal , Humans , Immune System , Pandemics/prevention & control , Pandemics/veterinary , Pneumonia, Viral/immunology , Pneumonia, Viral/prevention & control , Pneumonia, Viral/veterinarySubject(s)
Allergy and Immunology , Asthma , Hypersensitivity , Educational Status , Humans , United States/epidemiologySubject(s)
Allergy and Immunology , Hypersensitivity , Vaccines , Allergists , Humans , Vaccines/adverse effectsABSTRACT
The Federation of Clinical Immunology Societies (FOCIS) regularly organizes scientific meetings to foster advances in immunology. A new event of this type is FOCIS Goes South, a course and workshop organized by FOCIS Centers of Excellence (FCEs) from across Latin America, which consists of a course on advanced immunology, a flow cytometry workshop and seminars on cutting-edge research in autoimmunity, tolerance, cancer, infectious diseases and vaccines. Due to the COVID-19 pandemic, the second version of FOCIS Goes South, hosted by the Millennium Institute on Immunology and Immunotherapy in Chile, took place virtually from 15 to 18 November 2021, with more than 950 registered participants. The present article summarizes the key findings and insights discussed at FOCIS Goes South 2021.
Subject(s)
Allergy and Immunology , COVID-19 , Neoplasms , COVID-19/therapy , Chile , Humans , Immunotherapy , PandemicsABSTRACT
Bo Zhong studies the regulation of the antiviral innate immunity, inflammation, and tumorigenesis by the protein ubiquitination system.
Subject(s)
Allergy and Immunology/history , Immunity, Innate , Ubiquitination , Virology/history , Animals , China , History, 21st Century , Host-Pathogen Interactions , HumansSubject(s)
Allergy and Immunology , Biomedical Research , Hypersensitivity , COVID-19 , Congresses as Topic , Delivery of Health Care, Integrated , Humans , Hypersensitivity/epidemiology , Hypersensitivity/immunology , Hypersensitivity/microbiology , Hypersensitivity/virology , Microbiota/immunology , Pollen/immunology , VideoconferencingSubject(s)
Allergy and Immunology , Asthma/epidemiology , COVID-19/epidemiology , Hypersensitivity/epidemiology , SARS-CoV-2/physiology , Allergists , Asthma/immunology , COVID-19/immunology , Health Status Disparities , Healthcare Disparities , Humans , Hypersensitivity/immunology , Pandemics , Patient Education as Topic , Socioeconomic FactorsABSTRACT
The use of minimal peptide sets offers an appealing alternative for design of vaccines and T cell diagnostics compared to conventional whole protein approaches. T cell immunogenicity towards peptides is contingent on binding to human leukocyte antigen (HLA) molecules of the given individual. HLA is highly polymorphic, and each variant typically presents a different repertoire of peptides. This polymorphism combined with pathogen diversity challenges the rational selection of peptide sets with broad immunogenic potential and population coverage. Here we propose PopCover-2.0, a simple yet highly effective method, for resolving this challenge. The method takes as input a set of (predicted) CD8 and/or CD4 T cell epitopes with associated HLA restriction and pathogen strain annotation together with information on HLA allele frequencies, and identifies peptide sets with optimal pathogen and HLA (class I and II) coverage. PopCover-2.0 was benchmarked on historic data in the context of HIV and SARS-CoV-2. Further, the immunogenicity of the selected SARS-CoV-2 peptides was confirmed by experimentally validating the peptide pools for T cell responses in a panel of SARS-CoV-2 infected individuals. In summary, PopCover-2.0 is an effective method for rational selection of peptide subsets with broad HLA and pathogen coverage. The tool is available at https://services.healthtech.dtu.dk/service.php?PopCover-2.0.